Tags: Enzyme.
Histone deacetylases (EC 3.5.1.98 HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase.
