Tags: Protein.
Histidine triad nucleotide-binding protein 1 is a protein that in humans is encoded by the HINT1 gene. It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and Microphthalmia-associated transcription factor (MITF) activity in human mast cells. In the LysRS-Ap4A-MITF signaling pathway HINT1 inhibits the MITF transcriptional activity by direct association.