Tags: Chemical Compound, Chemical Substance.

Hemorphin-4 is an endogenous opioid peptide of the hemorphin family which possesses antinociceptive properties and is derived from the β-chain of hemoglobin in the bloodstream. It is a tetrapeptide with the amino acid sequence Tyr-Pro-Trp-Thr. Hemorphin-4 has affinities for the μ- δ- and κ-opioid receptors that are in the same range as the structurally related β-casomorphins although affinity to the κ-opioid receptor is markedly higher in comparison. It acts as an agonist at these sites.

Hemorphin_4.svg
IUPAC name
(2S3R)-2-(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoic acid

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