Tags: Protein.
Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis in humans a severe form of hemochromatosis. In humans the hemojuvelin protein is encoded by the HFE2 gene. HJV is also called RGMc a member of a three gene family (in vertebrates) called the repulsive guidance molecules. Both RGMa and RGMb are found in the nervous system while RGMc is found in skeletal muscle and the liver.