Hemicholinium-3 (HC3) also known as hemicholine is a drug which blocks the reuptake of choline by the high-affinity choline transporter (ChT; encoded in humans by the gene SLC5A7) at the presynapse. The reuptake of choline is the rate limiting step in the synthesis of acetylcholine; hence hemicholinium-3 decreases the synthesis of acetylcholine.
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