Tags: Protein.
In molecular biology the HECT domain is a protein domain found in ubiquitin-protein ligases. The name HECT comes from ‘Homologous to the E6-AP Carboxyl Terminus’. Proteins containing this domain at the C terminus include ubiquitin-protein ligase which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
