Tags: Protein.
Heat shock protein 47 also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen.This protein a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis.