Tags: Protein.
In molecular biology the HAND domain is a protein domain which adopts a secondary structure consisting of four alpha helices three of which (H2 H3 H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4 packing closely against helix H4 whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. This domain confers DNA and nucleosome binding properties to the proteins in which it occurs.
