Tags: Chemical Compound, Chemical Substance.
(p)ppGpp guanosine pentaphosphate or tetraphosphate is an alarmone which is involved in the stringent response in bacteria causing the inhibition of RNA synthesis when there is a shortage of amino acids present. This causes translation to decrease and the amino acids present are therefore conserved. Furthermore ppGpp causes the up-regulation of many other genes involved in stress response such as the genes for amino acid uptake (from surrounding media) and biosynthesis.
