Tags: Drug.
Guanethidine is an antihypertensive drug that reduces the release of catecholamines such as norepinephrine. Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET uptake 1) and uptake is essential for the drug’s action. Once guanethidine has entered the nerve it is concentrated in transmitter vesicles where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine.
