Tags: Protein.
Gremlin is an inhibitor in the TGF beta signaling pathway.Gremlin also known as Drm is a highly conserved 20.7-kDa 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein. Gremlin was first identified in differential screening as a transcriptional down-regulated gene in v-mos-transformed rat embryonic fibrolasts.Gremlin 1 (grem 1) is known for its antagonistic reaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling pathway.