Tags: Protein.
GMP reductase EC 1.7.1.7 (Guanosine 5′-monophosphate oxidoreductase ) is an enzyme that catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP.NADPH + guanosine 5-phosphate = NADP+ + inosine 5-phosphate + NH3It converts nucleobase nucleoside and nucleotide derivatives of G to A nucleotides and maintains intracellular balance of A and G nucleotides.In melanocytic cells GMP reductase gene expression may be regulated by MITF.