Tags: Enzyme.
Glutamate dehydrogenase (GLDH) is an enzyme present in most microbes and the mitochondria of eukaryotes as are some of the other enzymes required for urea synthesis that converts glutamate to α-ketoglutarate and vice versa. In animals the produced ammonia is usually used as a substrate in the urea cycle. Typically the α-ketoglutarate to glutamate reaction does not occur in mammals as glutamate dehydrogenase equilibrium favours the production of ammonia and α-ketoglutarate.