Tags: Protein.
The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK) thereby controlling both activity and intracellular location of this key enzyme of glucose metabolism.GKRP is a 68 kD protein of 626 amino acids. It is coded for by a 19 exon gene GCKR on the short arm of chromosome 2 (2p23). GKRP was discovered by Emile van Schaftingen and reported in 1989