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Gerstmann–Sträussler–Scheinker syndrome (GSS) is a very rare usually familial fatal neurodegenerative disease that affects patients from 20 to 60 years in age.[citation needed] This extremely rare disease is classified as a transmissible spongiform encephalopathy (TSE).The exact incidence of GSS is unknown but is estimated to be between 1 and 10 per 100 million.[citation needed]Familial cases are associated with autosomal-dominant inheritance.Gerstmann-Straussler-Scheinker Disease (GSS) is an extremely rare neurogenetic brain disorder.

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