Tags: Anatomical Structure.
Germinal centers (or germinal centres; GC) are sites within secondary lymphoid organs where mature B lymphocytes proliferate differentiate mutate their antibodies (through somatic hypermutation) and switch the class of their antibodies (for example from IgM to IgG) during a normal immune response to an infection. During this process of rapid division and selection B cells are known as centroblasts and once they have stopped proliferating they are known as centrocytes.
