Tags: Protein.
Gephyrin is a multi-functional protein that is a component of the postsynaptic protein network of inhibitory synapses. It consists of 3 domains: N terminal G domain C terminal E domain and a large unstructured linker domain which connects the two. Although there are structures available for trimeric G and dimeric E domains there is no structure available for the full length protein which may be due to the large unstructured region which makes the protein hard to crystallize.