Tags: Chemical Compound, Chemical Substance.
Geldanamycin is a benzoquinone ansamycin antibiotic that inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein. HSP90 client proteins play important roles in the regulation of the cell cycle cell growth cell survival apoptosis angiogenesis and oncogenesis.Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src Bcr-Abl and p53 preferentially over their normal cellular counterparts.
