Tags: Chemical Compound, Chemical Substance.

GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin including human neuroblastoma and melanoma with highly restricted expression on normal tissues principally to the cerebellum and peripheral nerves in humans. The relatively tumor specific expression of GD2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors.

GD2_ganglioside.png
IUPAC name
(2R4R5S6S)-2-[3-[(2S3S4R6S)-6-[(2S3R4R5S6R)-5-[(2S3R4R5R6R)-3-acetamido-45-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R3S4R5R6R)-45-dihydroxy-2-(hydroxymethyl)-6-[(E)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3-amino-6-carboxy-4-hydroxyoxan-2-yl]-23-dihydroxypropoxy]-5-amino-4-hydroxy-6-(123-trihydroxypropyl)oxane-2-carboxylic acid

Loading...

This page contains content from the copyrighted Wikipedia article "GD2"; that content is used under the GNU Free Documentation License (GFDL). You may redistribute it, verbatim or modified, providing that you comply with the terms of the GFDL.