Tags: Anatomical Structure.
A gastric chief cell (or peptic cell or gastric zymogenic cell) is a cell in the stomach that releases pepsinogen gastric lipase and chymosin. The cell stains basophilic upon H&E prep due to the large proportion of rough endoplasmic reticulum in its cytoplasm. Gastric chief cells are generally located deep in the mucosal layer of the stomach lining.