Ganaxolone (INN also known as CCD-1042) is a synthetic neuroactive steroid related to allopregnanolone that has sedative anxiolytic and anticonvulsant effects. It is a potent and selective positive allosteric modulator of GABAA receptors. Ganaxolone protects against seizures in diverse animal models including the pentylenetetrazol 6 Hz and amygdala kindling models.
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