Tags: Chemical Compound, Chemical Substance.
Gamendazole is a novel drug candidate for male contraception. It is an indazole carboxylic acid derived from lonidamine (LND). Gamendazole produced 100% antispermatogenic effects at 25 mg/kg i.p. in rats whereas 200 mg/kg was fatal for 60% of rats tested. Since gamendazole produced 100% efficacy it was tested orally. At a dose of 6 mg/kg 100% of rats were infertile 4 weeks after a single administration.
