Folinic acid (INN) or leucovorin /luːkoʊˈvɔːrɪn/ (USAN) generally administered as calcium or sodium folinate (or leucovorin calcium/sodium) is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is also used in synergistic combination with the chemotherapy agent 5-fluorouracil.Levofolinic acid and its salts are the enantiopure drugs (in this case the levo form) and are the only molecules that are biologically active.
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