Tags: Protein.
Filamin B beta (FLNB) also known as Filamin B beta (actin binding protein 278) is a cytoplasmic protein which in humans is encoded by the FLNB gene.FLNB regulates intracellular communication and signalling by cross-linking the protein actin to allow direct communication between the cell membrane and cytoskeletal network to control and guide proper skeletal development.Mutations in the FLNB gene are involved in several lethal bone dysplasias including boomerang dysplasia and atelosteogenesis type I.