Fibrinogen (factor I) is a soluble 340 kDa plasma glycoprotein that is converted by thrombin into fibrin during blood clot formation. Fibrinogen is synthesized in the liver by the hepatocytes. The concentration of fibrinogen in the blood plasma is 200–400 mg/dL (normally measured using the Clauss method).During normal blood coagulation a coagulation cascade activates the zymogen prothrombin by converting it into the serine protease thrombin.
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