Fialuridine or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU) is a nucleoside analogue. It was originally designed as a therapy for hepatitis B virus infection. In a 1992 clinical study at the NIH unexpected toxicity led to the death of 5 out of 15 patients from fulminant liver failure associated with lactic acidosis. This toxicity was unusual in that it was not predicted by animal studies.
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