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Febrile non-hemolytic transfusion reaction is a type of transfusion reaction that is associated with fever but not directly with hemolysis. Most commonly caused by antibodies directed against donor leukocytes and HLA antigens.It is abbreviated FNHTR.The reaction can be mediated by cytokines.Acetaminophen and diphenhydramine have been used in treatment and leukoreduction of future transfusions is sometimes performed.

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