The high-affinity IgE receptor also known as FcεRI or Fc epsilon RI is the high-affinity receptor for the Fc region of immunoglobulin E (IgE) an antibody isotype involved in the allergy disorder and parasites immunity. FcεRI is a tetrameric receptor complex consisting of one alpha (FcεRIα – antibody binding site) one beta (FcεRIβ – which amplifies the downstream signal) and two disulfide bridge connected gamma chains (FcεRIγ – the site where the downstream signal initiates).
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arm
q
band
23
chromosome
1
EntrezGene
2207, 2205, 2206
HGNCid
3611, 3609, 7316
OMIM id
147138, 147139, 147140
RefSeq
NM_000139, NM_002001, NM_004106
symbol
FCER1A, FCER1G, FcεRIα FCE1A, FcεRIβ FCER1B IGER APY, FcεRIγ, MS4A2
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