Tags: Protein.
Estrogen-related receptor alpha (ERR-α) also known as NR3B1 (nuclear receptor subfamily 3 group B member 1) is a nuclear receptor that in humans is encoded by the ESRRA (Estrogen Related Receptor Alpha) gene. ERR-α was originally cloned by DNA sequence homology to the estrogen receptor alpha (ER-α NR3A1) but subsequent ligand binding and reporter-gene transfection experiments demonstrated that estrogens did not regulate ERR-α. Currently ERRα is considered an orphan nuclear receptor.