Tags: Protein.
The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 59 kDa peptide and is a member of the cytokine receptor family. EpoR pre-exists as dimers which upon binding of a 34 kDa ligand erythropoietin (Epo) changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e. EpoR does not possess intrinsic kinase activity and depends on Jak2 activity).
