Tags: Protein.
Prostaglandin E receptor 1 (subtype EP1) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system Gq proteins mediate this receptor’s activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure.