Tags: Chemical Compound, Chemical Substance.

Enzastaurin is a synthetic bisindolylmaleimide with potential antineoplastic activity. Binding to the ATP-binding site enzastaurin selectively inhibits protein kinase C beta an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply preventing growth.In 2013 it failed a phase III clinical trial for lymphoma.

Enzastaurin.png
FDA UNII code
UC96G28EQF
IUPAC name
3-(1-Methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-25-dione

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