Tags: Protein.
Endothelin 1 also known as preproendothelin-1 (PPET1) is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin (ET-1). Preproendothelin is precursor of the peptide ET-1.