Tags: Chemical Compound, Chemical Substance.

Endomorphins are two endogenous opioid peptides. Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are tetrapeptides with the highest known affinity and specificity for the μ opioid receptor. Endomorphin-1 is located in the nucleus of the solitary tract the periventricular hypothalamus and the dorsomedial hypothalamus where it is found within histaminergic neurons and may regulate sedative and arousal behaviors.

Endomorphin_1.svg
IUPAC name
(L)-Tyrosyl-(L)-prolyl-(L)-phenylalanyl-(L)-phenylalaninamide (Endmorphin-2), (L)-Tyrosyl-(L)-prolyl-(L)-tryptophyl-(L)-phenylalaninamide (Endmorphin-1)

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