Tags: Chemical Compound, Chemical Substance.
Edelfosine (ET-18-O-CH3 ; 1-octadecyl-2-O-methyl-glycero-3-phosphocholine) is a synthetic alkyl-lysophospholipid (ALP). It has antineoplastic (anti-cancer) effects.Like all ALPs it incorporates into the cell membrane and does not target the DNA. In many tumor cells it causes selective apoptosis sparing healthy cells. Edelfosine can activate the Fas/CD95 cell death receptor can inhibit the MAPK/ERK mitogenic pathway and the Akt/protein kinase B (PKB) survival pathway.
