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Eczema vaccinatum is a rare severe adverse reaction to smallpox vaccination. It is characterized by serious local or disseminated umbilicated vesicular crusting skin rashes in the face neck chest abdomen upper limbs and hands caused by widespread infection of the skin in people with previous diagnosed skin conditions such as eczema or atopic dermatitis even if the conditions are not active at the time. Other signs and symptoms include fever and facial and supraglottic edema.

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