Tags: Chemical Compound, Chemical Substance.
E-6837 is an orally active 5-HT6 agonist developed in an attempt to create an anti-obesity medication. In cell lines expressing rat 5-HT6 receptors it acted as a partial agonist (on presumed silent receptors) while it acted as a full agonist on human 5-HT6 receptors (which are constitutively active). Oral administration of E-6837 reduced food intake but only transiently.
