Droxidopa (INN; trade name Northera; also known as L-DOPS L-threo-dihydroxyphenylserine and SM-5688) is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Unlike norepinephrine and epinephrine themselves droxidopa is capable of crossing the protective blood–brain barrier (BBB).
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