Tags: Protein.

Doubletime (dbt) also known as discs overgrown (dco) is a gene that encodes the double-time protein (DBT) in Drosophila melanogaster. The double-time protein is a kinase that phosphorylates PER protein that regulates the molecularly-driven biological clock controlling circadian rhythm. The mammalian homolog of doubletime is casein kinase I epsilon. Different Mutations in the dbt gene have been shown to cause lengthening shortening or complete loss in period of locomotor activity in flies.

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