Tags: Protein.
Doubletime (dbt) also known as discs overgrown (dco) is a gene that encodes the double-time protein (DBT) in Drosophila melanogaster. The double-time protein is a kinase that phosphorylates PER protein that regulates the molecularly-driven biological clock controlling circadian rhythm. The mammalian homolog of doubletime is casein kinase I epsilon. Different Mutations in the dbt gene have been shown to cause lengthening shortening or complete loss in period of locomotor activity in flies.