Tags: Enzyme.
In enzymology a diphthine-ammonia ligase (EC 6.3.1.14 diphthamide synthase diphthamide synthetase) is an enzyme that catalyzes the chemical reactionATP + diphthine + NH3 ADP + phosphate + diphthamideThe 3 substrates of this enzyme are ATP diphthine and NH3 whereas its 3 products are ADP phosphate and diphthamide.This enzyme belongs to the family of ligases specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases).