Tags: Enzyme.
Dihydroceramide desaturase is the enzyme involved in the conversion of dihydroceramide into ceramide by inserting the 45-trans-double bond to the sphingolipid backbone of dihydroceramide. DDase require the O2 and the NAD(P)H as cofactor.The activity of DDase is influenced by several factors as 1.alkyl chain length of the sphingoid base (in the order C18 > C12 > C8) and fatty acid (C8 > C18)2.