Tags: Protein.
Cytolethal distending toxins (abbreviated CDTs) are a class of heterotrimeric toxins produced by certain gram-negative bacteria that display DNase activity. These toxins trigger G2/M cell cycle arrest in specific mammalian cell lines leading to the enlarged or distended cells for which these toxins are named. Affected cells die by apoptosis.Each toxin consists of three distinct subunits named alphabetically in the order that their coding genes appear in the cdt operon.
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