Tags: Chemical Compound, Chemical Substance.
The cortistatins are a group of steroidal alkaloids first isolated in 2006 from the marine sponge Corticium simplex. The cortistatins inhibit proliferation of human umbilical vein endothelial cells (HUVECs) with high selectivity with cortistatin A being the most potent compound in the class. Cortistatin A represses viral replication in cells infected with HIV via binding to the Tat protein.
