Tags: Protein.
Cofactor of BRCA1 also known as COBRA1 is a human gene that encodes NELF-B. NELF-B is a subunit of negative elongation factor (NELF) which also includes NELF-A (WHSC2; MIM 606026) either NELF-C or NELF-D (TH1L; MIM 605297) and NELF-E (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF) a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102) to cause transcriptional pausing of RNA polymerase II (see MIM 180660).