Tags: Protein.

Cofactor of BRCA1 also known as COBRA1 is a human gene that encodes NELF-B. NELF-B is a subunit of negative elongation factor (NELF) which also includes NELF-A (WHSC2; MIM 606026) either NELF-C or NELF-D (TH1L; MIM 605297) and NELF-E (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF) a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102) to cause transcriptional pausing of RNA polymerase II (see MIM 180660).

Loading...

This page contains content from the copyrighted Wikipedia article "Cofactor of BRCA1"; that content is used under the GNU Free Documentation License (GFDL). You may redistribute it, verbatim or modified, providing that you comply with the terms of the GFDL.