Tags: Chemical Compound, Chemical Substance.

Codinaeopsin is an antimalarial isolated from a fungal isolate found in white yemeri trees (Vochysia guatemalensis) in Costa Rica. It is reported to have bioactivity against Plasmodium falciparum with an IC50 = 2.3 µg/mL (4.7 µM). Pure codinaeopsin was reported to be isolated with a total yield of 18 mg/mL from cultured fungus. The biosynthesis of codinaeopsin is manufactured by a polyketide synthase- nonribosomal peptide synthetase (PKS-NRPS) hybrid.

Codinaeopsin.png
IUPAC name
5-((1H-indol-3-yl)methyl)-3-((1R2R4aS6R8S8aS)-2-((E)-but-2-en-2-yl)-4a68-trimethyl-124a56788a-octahydronaphthalene-1-carbonyl)-5-hydroxy-1H-pyrrol-2(5'H)-one

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