Tags: Enzyme.
Cobalt chelatase (EC 6.6.1.2) is an enzyme that catalyzes the chemical reactionATP + hydrogenobyrinic acid ac-diamide + Co2+ + H2O ADP + phosphate + cob(II)yrinic acid ac-diamide + H+The 4 substrates of this enzyme are ATP hydrogenobyrinic acid ac-diamide Co2+ and H2O whereas its 4 products are ADP phosphate cob(II)yrinic acid ac-diamide and H+.The aerobic cobalt chelatase (aerobic cobalamin biosynthesis pathway) consists of three subunits CobT CobN (IPR003672) and CobS (IPR006537).Cobalamin (vitamin B12) can be complexed with metal via the ATP-dependent reactions (aerobic pathway) (e.g. in Pseudomonas denitrificans) or via ATP-independent reactions (anaerobic pathway) (e.g. in Salmonella typhimurium).
