Tags: Drug.
Clozapine is an atypical antipsychotic medication used in the treatment of schizophrenia and is also sometimes used off-label for the treatment of bipolar disorder. The first of the atypical antipsychotics to be developed it was first introduced in Europe in 1971 but was voluntarily withdrawn by the manufacturer in 1975 after it was shown to cause agranulocytosis a condition involving a dangerous decrease in the number of white blood cells that led to death in some patients.
