Tags: Drug.
CGS-15943 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors A1 and A2A having a Ki of 3.3nM at A2A and 21nM at A1. It was one of the first adenosine receptor antagonists discovered that is not a xanthine derivative instead being a triazoloquinazoline. Consequently CGS-15943 has the advantage over most xanthine derivatives that it is not a phosphodiesterase inhibitor and so has more a specific pharmacological effects profile.
