Tags: Chemical Compound, Chemical Substance.
Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. In fatty acid synthesis it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase one of the seven moieties of fatty acid synthase blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1 another enzyme normally inhibited by malonyl-CoA.
