Cefalotin (INN) /ˌsɛfəˈloʊtɨn/ or cephalothin (USAN) /ˌsɛfəˈloʊθɨn/ is a first-generation cephalosporin antibiotic. It was the first cephalosporin marketed (1964) and continues to be widely used. It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is commonly marketed under the trade name Keflin (Lilly).
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